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Victoria's avatar

Excellent -- thank you -- so grateful you're able to do this work. Deep bow.

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SEF's avatar

Although no one can say for certain, my guess is that fluvoxamine works well but ivermectin works even better. I remember one doctor saying he has treated over 1000 patients (many high-risk) with a combination of the two, and only had a single digit number of hospitalizations and no deaths. What is unfathomably reprehensible is that TOGETHER gave fluvoxamine for 10 days (which is good) but ivermectin for only 3 days (!!!). In spite of this colossal disadvantage for ivermectin, there's STILL an effect seen here that is nothing to sneeze at, and taking other things into account the 3-day ivermectin effect actually starts to approach the 10-day fluvoxamine effect, as you suggest.

Looking at other ivermectin RCTs overall, which also predominantly used inadequate regimens (though most were not as badly "designed to fail" as TOGETHER), clearly shows that ivermectin works: to what extent is the question. What settles the question for me is the largest 5-day ivermectin RCT (I-TECH) showing a very impressive effect: 70% reduction in mortality among hospitalized patients. The establishment was so relieved, thrilled, and gleeful that this (barely) missed statistical significance. "So there's only like 91% confidence (instead of the magic 95%) that ivermectin reduces mortality, which means we can and will continue to strongly advise AGAINST its use."

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